Tuesday 23 March 2010

Three-person IVF may prevent inherited ills





British scientists have mastered a controversial artificial reproduction technique that could prevent incurable inherited diseases by swapping DNA between two fertilized human eggs.

Lead researcher Doug Turnbull of Newcastle University said on Wednesday he hoped the first babies free from so-called mitochondrial diseases would be born within three years.

But applying the technique in the clinic, to help women at risk of passing on the disorders, will require a change in British law that currently bans reproduction from such manipulated embryos.

Around one in 6,500 children are born with serious diseases caused by malfunctioning mitochondrial DNA, leading to a range of conditions that can include fatal heart problems, liver failure, brain disorders, blindness and muscular weakness.

The Newcastle team's technique effectively replaces mitochondria, which act as tiny energy-generating batteries inside cells, so a baby doesn't inherit faults from its mother. Mitochondria are only passed down the maternal line.

"What we've done is like changing the battery on a laptop. The energy supply now works properly, but none of the information on the hard drive has been changed," Turnbull said.

"A child born using this method would have correctly functioning mitochondria, but in every other respect would get all their genetic information from their father and mother."

Within a day of fertilization, using in vitro fertilization, nuclear DNA is removed from the embryo and implanted into a donor egg, whose own genetic material has been removed and discarded.

The resulting fetus inherits nuclear DNA, or genes, from both its parents but mitochondrial DNA from a second "mother."

For critics like Josephine Quintavalle of campaign group Comment on Reproductive Ethics that makes it "a step too far in meddling with the building blocks of human life."

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